| dc.contributor.author | Simanjuntak, Leo | |
| dc.contributor.author | Siregar, M Fidel Ganis | |
| dc.contributor.author | Johannes C, Mose | |
| dc.contributor.author | Sarma N, Lumbanraja | |
| dc.date.accessioned | 2019-07-30T03:46:49Z | |
| dc.date.available | 2019-07-30T03:46:49Z | |
| dc.date.issued | 2018-09-21 | |
| dc.identifier.uri | http://repository.uhn.ac.id/handle/123456789/2614 | |
| dc.description | Introduction : Preeclampsia is a major cause in both maternal and perinatal mortality
and morbidity. The etiopathogenesis of preeclampsia remains unclear but endothelial
dysfunction plays important role. Stress oxidative in placenta produces free radicals
such as superoxide anions (O2-) and H2O2, trophoblast debris, pro-inflammatory
cytokines, and antiangiogenic factors which are thought to cause vascular endothelial
dysfunction and causing excessive maternal inflammatory responses. Tumor Necrosis
Factor-α (TNF-α) is considered as one of the potentially specific markers for
preeclampsia.
Aim : This study aimed to determine the effects of Phaleria macrocarpa (Scheff.)
Boerl Extract on inflammation in endothelial cells by measuring the TNF-α level In
preeclampsia-induced HUVEC.
Method : HUVEC (Human Umbilical Vein Endothelial Cell) culture is an in vitro
model widely used to study the pathogenesis of preeclampsia. Phaleria macrocarpa
(Scheff.) Boerl also known as Mahkota Dewa is widely used as an anti-inflammation
and antioxidant because of alkaloids, saponins, flavonoids and polyphenols
properties.
Result : Phaleria macrocarpa extract reduced TNF-α level siginifcantly at
concentration of 3.906 μg/mL. Phaleria macrocarpa extract at concentration of 62.5
μg/mL reduced TNF-α level to normal level.
Conclusion : Phaleria macrocarpa extract might be used as agent to overcome
endothelial dysfunction in preeclampsia. | en_US |
| dc.publisher | 1st International Conference on Neuroscience, Neurology and Psychiatry 2018 | en_US |
| dc.subject | Phaleria macrocarpa | en_US |
| dc.subject | preeclampsia | en_US |
| dc.subject | HUVEC | en_US |
| dc.subject | TNF-α | en_US |
| dc.title | The Effects of Phaleria macrocarpa (Scheff.) Boerl Extract on Tumor Necrosis Factor-Alpha (TNF-α) Level in Preeclampsia-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Culture | en_US |
